Identification of Germline Mismatch Repair Gene Mutations in Lung Cancer Patients With Paired Tumor-Normal Next Generation Sequencing: A Retrospective Study

Abstract excerpt

Background: Identification of the pathogenic germline mutation in DNA mismatch repair (MMR) genes is one of the diagnostic criteria of Lynch syndrome. In retrospective analysis of germline mutations of lung cancer patients, we accidentally found germline mutations on MMR genes in these patients. As lung cancer is not one of the common manifestation of Lynch syndrome, we aims to investigate whether the development...

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