Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HMGB1 modulates the balance between senescence and apoptosis in response to genotoxic stress

5 Jul 2019

Abstract excerpt

ABSTRACT High mobility group box‐1 (HMGB1) is involved in various diseases and is associated with the resistance of many types of human cancers to chemotherapy; however, its role in cancer metastasis remains unexplored. This study examined the HMGB1 status of both highly and poorly metastatic cancer cells in response to genotoxic stress. The weakly and highly metastatic mouse melanoma cell lines (B16 vs ....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced Glycation End Products research
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31284735
DOI: 10.1096/fj.201900288r

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HMGB1 modulates the balance between senescence and apoptosis in response to genotoxic stressPMID 31284735Read ↗

HMGB1 assists in overcoming cisplatin resistance in chemoresistant human ovarian cancer cellsSemantic proximity Read ↗

Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence.Semantic proximity Read ↗

Mechanisms involved in the HMGB1 modulation of tumor multidrug resistance (Review)Semantic proximity Read ↗

Cyclin D1 promotes radioresistance through regulation of RAD51 in melanomaSemantic proximity Read ↗

Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug ResistanceSemantic proximity Read ↗

Premature senescence is a major response to DNA cross-linking agents in BRCA1-defective cells: implication for tailored treatments of BRCA1 mutation carriersSemantic proximity Read ↗

SIRT1 regulates Mxd1 during malignant melanoma progressionSemantic proximity Read ↗

p53/HMGB1 Complexes Regulate Autophagy and ApoptosisSemantic proximity Read ↗

Persistent <scp>DNA</scp> damage‐induced premature senescence alters the functional features of human bone marrow mesenchymal stem cellsSemantic proximity Read ↗

Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.Semantic proximity Read ↗

Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer.Semantic proximity Read ↗

BRCA1 shifts p53-mediated cellular outcomes towards irreversible growth arrest.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.