Article
Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.
Pigment cell & melanoma research - 1 Mar 2015
Webster Marie R, Xu Mai, Kinzler Kathryn A, Kaur Amanpreet, Appleton Jessica, O'Connell Michael P, Marchbank Katie, Valiga Alexander, Dang Vanessa M, Perego Michela, Zhang Gao, Slipicevic Ana, Keeney Frederick, Lehrmann Elin, Wood William, Becker Kevin G, Kossenkov Andrew V, Frederick Dennie T, Flaherty Keith T, Xu Xiaowei, Herlyn Meenhard, Murphy Maureen E, Weeraratna Ashani T
Abstract excerpt
We have previously shown that Wnt5A drives invasion in melanoma. We have also shown that Wnt5A promotes resistance to therapy designed to target the BRAF(V600E) mutation in melanoma. Here, we show that melanomas characterized by high levels of Wnt5A respond to therapeutic stress by increasing p21 and expressing classical markers of senescence, including positivity for senescence-associated β-galactosidase...
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