Article
Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer.
Cancer letters - 28 Mar 2015
George Babitha, Horn Dominik, Bayo Pilar, Zaoui Karim, Flechtenmacher Christa, Grabe Niels, Plinkert Peter, Krizhanovsky Valery, Hess Jochen
Abstract excerpt
Myb-binding protein 1A (MYBBP1A) is a nucleolar protein implicated in stress response and carcinogenesis; however, its functional contribution to senescence remains elusive. In this study we show decreased MYBBP1A protein levels in tumor cells after treatment with etoposide, a potent inducer of DNA damage. Although silencing of MYBBP1A expression was not sufficient to induce senescence, it significantly increased...
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