Article
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde.
Cell - 27 Dec 2002
Hu Min, Li Pingwei, Li Muyang, Li Wenyu, Yao Tingting, Wu Jia-Wei, Gu Wei, Cohen Robert E, Shi Yigong
Abstract excerpt
The ubiquitin-specific processing protease (UBP) family of deubiquitinating enzymes plays an essential role in numerous cellular processes. HAUSP, a representative UBP, specifically deubiquitinates and hence stabilizes the tumor suppressor protein p53. Here, we report the crystal structures of the 40 kDa catalytic core domain of HAUSP in isolation and in complex with ubiquitin aldehyde. These studies reveal that...
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