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The role of sirtuins in cardiac disease

1 Aug 2015

Abstract excerpt

Modification of histones is one of the important mechanisms of epigenetics, in which genetic control is determined by factors other than an individual's DNA sequence. Sirtuin family proteins, which are class III histone deacetylases, were originally identified as gene silencers that affect the mating type of yeast, leading to the name "silent mating-type information regulation 2" (SIR2). They are characterized by...

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PMID: 26232232
DOI: 10.1152/ajpheart.00053.2015

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