Article
VEGF-C promotes the development of lymphatics in bone and bone loss.
eLife - 5 Apr 2018
Hominick Devon, Silva Asitha, Khurana Noor, Liu Ying, Dechow Paul C, Feng Jian Q, Pytowski Bronislaw, Rutkowski Joseph M, Alitalo Kari, Dellinger Michael T
Abstract excerpt
Patients with Gorham-Stout disease (GSD) have lymphatic vessels in their bones and their bones gradually disappear. Here, we report that mice that overexpress VEGF-C in bone exhibit a phenotype that resembles GSD. To drive VEGF-C expression in bone, we generated Osx-tTA;TetO-Vegfc double-transgenic mice. In contrast to Osx-tTA mice, Osx-tTA;TetO-Vegfc mice developed lymphatics in their bones. We found that...
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