Back to search

Article

Estrogen Deficiency alters Vascularization and Mineralization dynamics: insight from a novel 3D Humanized and Vascularized Bone Organoid Model

2024-10-11

Abstract excerpt

Osteoporosis is not merely a disease of bone loss but also involves changes in the mineral composition of the bone that remains. In vitro studies have investigated these changes and revealed that estrogen deficiency alters osteoblast mineral deposition, osteocyte mechanosensitivity and osteocyte regulation of osteoclastogenesis. During healthy bone development, vascular cells stimulate bone mineralization via end...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
fd87ccaf-3ab8-54e7-9f89-6d157c436be3
DOI
10.1101/2024.10.09.614903
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Estrogen Deficiency alters Vascularization and Mineralization dynamics: insight from a novel 3D Humanized and Vascularized Bone Organoid ModelDOI 10.1101/2024.10.09.614903
Fundamentals of bone vasculature: Specialization, interactions and functionsSemantic proximity
Regulation of the Bone Vascular Network is Sexually DimorphicSemantic proximity
Diversity of Vascular Niches in Bones and Joints During Homeostasis, Ageing, and Diseases.Semantic proximity
Vascular calcification and osteoporosis--from clinical observation towards molecular understanding.Semantic proximity
Bioengineered human bone-mimetic niche compositions regulate breast cancer cell quiescence and therapy responseSemantic proximity
The Cellular Choreography of Osteoblast Angiotropism in Bone Development and HomeostasisSemantic proximity
A novel role of cellular interactions in vascular calcificationSemantic proximity
Cell-matrix signals specify bone endothelial cells during developmental osteogenesis.Semantic proximity
Mechanisms of Arterial Calcification: The Role of Matrix Vesicles.Semantic proximity
A molecular analysis of matrix remodeling and angiogenesis during long bone developmentSemantic proximity
Altered extracellular matrix and mechanotransduction gene expression in rat bone tissue following long-term estrogen deficiencySemantic proximity
Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progressionSemantic proximity
Select a neighboring publication to make it the new centre.