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Single-Cell mRNA Sequencing in Cancer Research: Integrating the Genomic Fingerprint

31 May 2017

Abstract excerpt

Critical cancer mutations are often regional and mosaic, confounding the efficacy of targeted therapeutics. Single cell mRNA sequencing (scRNA-seq) has enabled unprecedented studies of intra-tumor heterogeneity and its role in cancer progression, metastasis, and treatment resistance. When coupled with DNA sequencing, scRNA-seq allows one to infer the in vivo impact of genomic alterations on gene expression. This...

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PMID: 28620412
DOI: 10.3389/fgene.2017.00073

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