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Article

Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.

The Journal of reproduction and development - 1 Jun 2007

Ishida Maho, Choi Jae-hyek, Hirabayashi Keiji, Matsuwaki Takashi, Suzuki Masatoshi, Yamanouchi Keitaro, Horai Reiko, Sudo Katsuko, Iwakura Yoichiro, Nishihara Masugi

Abstract excerpt

In the corpus luteum of rats and mice, 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD) catalyzes the conversion of progesterone to a biologically inactive metabolite, 20alpha-dihydroprogesterone (20alpha-OHP). The reduction of progesterone by 20alpha-HSD is believed to be important for functional luteolysis in these rodent species. In addition to the corpus luteum, expression of 20alpha-HSD has been...

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Identifiers

PMID: 17272929
DOI: 10.1262/jrd.18125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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