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Article

Roles of Wnt/β-catenin signaling in the gastric cancer stem cells proliferation and salinomycin treatment

30 Jan 2014

Abstract excerpt

The Wnt1 protein, a secreted ligand that activates Wnt signaling pathways, contributes to the self-renewal of cancer stem cells (CSCs) and thus may be a major determinant of tumor progression and chemoresistance. In a series of gastric cancer specimens, we found strong correlations among Wnt1 expression, CD44 expression, and the grade of gastric cancer. Stable overexpression of Wnt1 increased AGS gastric cancer...

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PMID: 24481453
DOI: 10.1038/cddis.2013.515

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