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Homologous Recombination Deficiency: Concepts, Definitions, and Assays

1 Jan 2022

Abstract excerpt

BACKGROUND: Homologous recombination deficiency (HRD) is a phenotype that is characterized by the inability of a cell to effectively repair DNA double-strand breaks using the homologous recombination repair (HRR) pathway. Loss-of-function genes involved in this pathway can sensitize tumors to poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors and platinum-based chemotherapy, which target the...

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PMID: 35274707
DOI: 10.1093/oncolo/oyab053

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