Article

Towards Genomic Medicine: A Tailored Next-Generation Sequencing Panel for Hydroxyurea Pharmacogenomics in Tanzania

2023-08-25

Abstract excerpt

<title>Abstract</title> <p>Pharmacogenomics of hydroxyurea is an important aspect in the management of sickle cell disease (SCD), especially in the era of genomic medicine. Genetic variations in loci associated with HbF induction and drug metabolism are prime targets for hydroxyurea (HU) pharmacogenomics. This study investigated genetic variations in <italic>BCL11A, ARG2, HBB, HBG1, WAC, HBG2, HAO2, MYB, SAR1A, K...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d3bee539-e3f2-5c9f-aa5a-ee5ac370ddb8
DOI: 10.21203/rs.3.rs-3235315/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Towards Genomic Medicine: A Tailored Next-Generation Sequencing Panel for Hydroxyurea Pharmacogenomics in TanzaniaDOI 10.21203/rs.3.rs-3235315/v1Read

Exploring Pharmacogenetic Factors Influencing Hydroxyurea Response in Tanzanian Sickle Cell Disease Patients: A Genomic Medicine ApproachSemantic proximity Read

Exploring pharmacogenetic factors influencing hydroxyurea response in tanzanian sickle cell disease patients: a genomic medicine approach.Semantic proximity Read

Pharmacogenomics of Drugs Used in β-Thalassemia and Sickle-Cell Disease: From Basic Research to Clinical ApplicationsSemantic proximity Read

Identifying genetic variants and pathways associated with extreme levels of fetal hemoglobin in Sickle Cell Disease in Tanzania.Semantic proximity Read

KLF10 gene expression is associated with high fetal hemoglobin levels and with response to hydroxyurea treatment in β-hemoglobinopathy patients.Semantic proximity Read

Pharmacogenomics and therapeutics of hemoglobinopathies.Semantic proximity Read

Genetics and Genomics in Sickle Cell Disease in Africa.Semantic proximity Read

Genetic Approach in Diagnosis and Follow-Up of Patients with Thalassemia: A Comprehensive Narrative ReviewSemantic proximity Read

Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolismSemantic proximity Read

Identifying genetic variants and pathways associated with extreme levels of fetal hemoglobin in sickle cell disease in Tanzania.Semantic proximity Read

Hydroxyurea-Induced miRNA Expression in Sickle Cell Disease Patients in AfricaSemantic proximity Read

CYP2D6 Pharmacogenetics in Nigerian Sickle Cell Disease: Phase 1 of Implementing Pharmacogenomics Testing for Effective Care and Treatment in Africa (iPROTECTA) programSemantic proximity Read