Article
A novel reusable transcriptome-wide association study workflow used to map key genes linked to important cattle traits.
Genomics - 1 Sept 2026
Jayaraman S, Zhao R, Krishna Chitneedi P, Kumar Kadri N, Costa-Monteiro-Moreira G, Salavati M, Charlier C, Boichard D, Sanchez M-P, Pausch H, Kühn C, Prendergast J G D, Clark E L
Abstract excerpt
Transcriptome-wide association studies (TWAS) are a powerful approach for studying the genes underlying complex traits by directly integrating GWAS and gene expression datasets. In cattle, they have been previously applied to identify genes driving fertility, milk production, and health. However, these studies have also highlighted several challenges, from difficulties in reproducing these complex analyses to...
Read the complete abstract on PubMedTopics
- Animals
- Cattle
- Genome-Wide Association Study
- Transcriptome
- Workflow
- Quantitative Trait Loci