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Article

Structural basis for protein glutamylation by the Legionella pseudokinase SidJ.

Nature communications - 26 Oct 2021

Adams Michael, Sharma Rahul, Colby Thomas, Weis Felix, Matic Ivan, Bhogaraju Sagar

Abstract excerpt

Legionella pneumophila (LP) avoids phagocytosis by secreting nearly 300 effector proteins into the host cytosol. SidE family of effectors (SdeA, SdeB, SdeC and SidE) employ phosphoribosyl ubiquitination to target multiple host Rab GTPases and innate immune factors. To suppress the deleterious toxicity of SidE enzymes in a timely manner, LP employs a metaeffector named SidJ. Upon activation by host Calmodulin...

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Identifiers

PMID: 34702826
DOI: 10.1038/s41467-021-26429-y
PMCID: PMC8548325

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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