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Machine Learning-Enhanced T Cell Neoepitope Discovery for Immunotherapy Design

1 Jan 2019

Abstract excerpt

Immune responses mediated by T cells are aimed at specific peptides, designated T cell epitopes, that are recognized when bound to human leukocyte antigen (HLA) molecules. The HLA genes are remarkably polymorphic in the human population allowing a broad and fine-tuned capacity to bind a wide array of peptide sequences. Polymorphisms might generate neoepitopes by impacting the HLA-peptide interaction and...

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PMID: 31205413
DOI: 10.1177/1176935119852081

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