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Detection of NTRK Fusions: Merits and Limitations of Current Diagnostic Platforms

13 Jun 2019

Abstract excerpt

Abstract Oncogenic fusions involving NTRK1, NTRK2, and NTRK3 with various partners are diagnostic of infantile fibrosarcoma and secretory carcinoma yet also occur in lower frequencies across many types of malignancies. Recently, targeted small molecular inhibitor therapy has been shown to induce a durable response in a high percentage of patients with NTRK fusion–positive cancers, which has made the detection of...

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PMID: 31196931
DOI: 10.1158/0008-5472.can-19-0372

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