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Article

Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions.

The American journal of surgical pathology - 1 Nov 2017

Hechtman Jaclyn F, Benayed Ryma, Hyman David M, Drilon Alexander, Zehir Ahmet, Frosina Denise, Arcila Maria E, Dogan Snjezana, Klimstra David S, Ladanyi Marc, Jungbluth Achim A

Abstract excerpt

Activating neurotrophic tyrosine receptor kinase (NTRK) fusions, typically detected using nucleic-acid based assays, are highly targetable and define certain tumors. Here, we explore the utility of pan-TRK immunohistochemistry (IHC) to detect NTRK fusions. NTRK rearrangements were detected prospectively using MSK-IMPACT, a DNA-based next-generation sequencing assay. Transcription of novel NTRK rearrangements into...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28719467
DOI: 10.1097/PAS.0000000000000911
PMCID: PMC5636652

Genes

ETV6
NTRK3
IMPACT
LMNA
NTRK1
TPM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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