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NTRK gene fusion testing and management in lung cancer

3 Apr 2024

Abstract excerpt

Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are recurrent oncogenic drivers found in a variety of solid tumours, including lung cancer. Several tropomyosin receptor kinase (TRK) inhibitors have been developed to treat tumours with NTRK gene fusions. Larotrectinib and entrectinib are first-generation TRK inhibitors that have demonstrated efficacy in patients with TRK fusion lung cancers. Genomic...

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PMID: 38733648
DOI: 10.1016/j.ctrv.2024.102733

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