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Article

Phenotypic Effects of FGF4 Retrogenes on Intervertebral Disc Disease in Dogs

7 Jun 2019

Abstract excerpt

Two FGF4 retrogenes on chromosomes 12 (12-FGF4RG) and 18 (18-FGF4RG) contribute to short-limbed phenotypes in dogs. 12-FGF4RG has also been associated with intervertebral disc disease (IVDD). Both of these retrogenes were found to be widespread among dog breeds with allele frequencies ranging from 0.02 to 1; however, their additive contribution to disease is unknown. Surgical cases of IVDD (n = 569) were...

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PMID: 31181696
DOI: 10.3390/genes10060435

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