Article
Potential Modifying Loci Associated With Primary Lens Luxation, Pedal Hyperkeratosis, and Ocular Phenotypes in Miniature Bull Terriers.
Investigative ophthalmology & visual science - 1 Dec 2015
Gharahkhani Puya, O'Leary Caroline A, Duffy David L, Kyaw-Tanner Myat
Abstract excerpt
PURPOSE: Primary lens luxation (PLL) in dogs is an inherited disease in which the lens is displaced from its normal position. A truncating mutation in the ADAMTS17 orthologue on CFA03 is reported to cause PLL in several breeds, mostly terriers. However, the complex inheritance pattern of PLL in miniature bull terriers (MBTs) suggests that other loci may have a modifying effect on the ADAMTS17 mutation. This study...
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