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Article

Genome-wide association mapping in dogs enables identification of the homeobox gene, NKX2-8, as a genetic component of neural tube defects in humans.

PLoS genetics - 1 Jan 2013

Safra Noa, Bassuk Alexander G, Ferguson Polly J, Aguilar Miriam, Coulson Rochelle L, Thomas Nicholas, Hitchens Peta L, Dickinson Peter J, Vernau Karen M, Wolf Zena T, Bannasch Danika L

Abstract excerpt

Neural tube defects (NTDs) is a general term for central nervous system malformations secondary to a failure of closure or development of the neural tube. The resulting pathologies may involve the brain, spinal cord and/or vertebral column, in addition to associated structures such as soft tissue...

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PMID: 23874236
DOI: 10.1371/journal.pgen.1003646
PMCID: PMC3715436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23874236-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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