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Article

A specific isoform of Pyd/ZO-1 mediates junctional remodeling and formation of slit diaphragms

6 Jun 2019

Abstract excerpt

The podocyte slit diaphragm (SD), responsible for blood filtration in vertebrates, is a major target of injury in chronic kidney disease. The damage includes severe morphological changes with destabilization of SDs and their replacement by junctional complexes between abnormally broadened foot processes. In Drosophila melanogaster, SDs are present in nephrocytes, which filter the fly's hemolymph. Here, we show...

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PMID: 31171632
DOI: 10.1083/jcb.201810171

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