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Article

Sox2 is required for development of taste bud sensory cells.

Genes & development - 1 Oct 2006

Okubo Tadashi, Pevny Larysa H, Hogan Brigid L M

Abstract excerpt

Sox2 is expressed in basal epithelial cells of the tongue, with high levels in taste bud placodes, fungiform papillae, and mature taste cells, and low levels in filiform papillae. High Sox2 expression appears to lie downstream from canonical Wnt signaling. In hypomorphic Sox2(EGFP/LP) embryos, placodes form but no mature taste buds develop. In contrast, transgenic overexpression of Sox2 in the basal cells...

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Identifiers

PMID: 17015430
DOI: 10.1101/gad.1457106
PMCID: PMC1578692

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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