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Article

A noncoding point mutation of Zeb1 causes multiple developmental malformations and obesity in Twirler mice.

PLoS genetics - 1 Sept 2011

Kurima Kiyoto, Hertzano Ronna, Gavrilova Oksana, Monahan Kelly, Shpargel Karl B, Nadaraja Garani, Kawashima Yoshiyuki, Lee Kyu Yup, Ito Taku, Higashi Yujiro, Eisenman David J, Strome Scott E, Griffith Andrew J

Abstract excerpt

Heterozygous Twirler (Tw) mice develop obesity and circling behavior associated with malformations of the inner ear, whereas homozygous Tw mice have cleft palate and die shortly after birth. Zeb1 is a zinc finger protein that contributes to mesenchymal cell fate by repression of genes whose expression defines epithelial cell identity. This developmental pathway is disrupted in inner ears of Tw/Tw mice. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

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Share to Kruppel-Like Transcription Factors

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Share to Zinc Finger E-box-Binding Homeobox 1

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Identifiers

PMID: 21980308
DOI: 10.1371/journal.pgen.1002307
PMCID: PMC3183090

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