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BAL Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of Medications

4 Jun 2019

Abstract excerpt

Abstract Rationale Gene expression of BAL cells, which samples the cellular milieu within the lower respiratory tract, has not been well studied in severe asthma. Objectives To identify new biomolecular mechanisms underlying severe asthma by an unbiased, detailed interrogation of global gene expression. Methods BAL cell expression was profiled in 154 asthma and control subjects. Of these participants, 100 had...

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PMID: 31161938
DOI: 10.1164/rccm.201811-2221oc

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