Article
Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines.
The Journal of allergy and clinical immunology - 1 Jan 2008
Brasier Allan R, Victor Sundar, Boetticher Gary, Ju Hyunsu, Lee Chang, Bleecker Eugene R, Castro Mario, Busse William W, Calhoun William J
Abstract excerpt
BACKGROUND: Asthma is a heterogeneous clinical disorder. Methods for objective identification of disease subtypes will focus on clinical interventions and help identify causative pathways. Few studies have explored phenotypes at a molecular level. OBJECTIVE: We sought to discriminate asthma phenotypes on the basis of cytokine profiles in bronchoalveolar lavage (BAL) samples from patients with mild-moderate and...
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