Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

mRNA Delivery for Therapeutic Anti-HER2 Antibody Expression In Vivo

17 May 2019

Abstract excerpt

Antibody-based drugs are a leading class of biologics used to treat a variety of diseases, including cancer. However, wide antibody implementation is hindered by manufacturing challenges and high production cost. Use of in-vitro-transcribed mRNA (IVT-mRNA) for endogenous protein expression has the potential to circumvent many of the shortcomings of antibody production and therapeutic application. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Monoclonal and Polyclonal Antibodies Research
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31160223
DOI: 10.1016/j.ymthe.2019.05.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

mRNA Delivery for Therapeutic Anti-HER2 Antibody Expression In VivoPMID 31160223Read ↗

From structural design to delivery: mRNA therapeutics for cancer immunotherapySemantic proximity Read ↗

Advancements in mRNA Encoded Antibodies for Passive ImmunotherapySemantic proximity Read ↗

Antibody targeting facilitates effective intratumoral siRNA nanoparticle delivery to HER2-overexpressing cancer cellsSemantic proximity Read ↗

High-throughput <i>in vivo</i> screening using barcoded mRNA identifies lipid nanoparticles with extrahepatic tropism for cancer immunotherapySemantic proximity Read ↗

mRNA vaccines in tumor targeted therapy: mechanism, clinical application, and development trendsSemantic proximity Read ↗

Delivery of mRNA encoding an anti-tau monoclonal antibody and engineered scFv intrabody results in functional antibody expression in SH-SY5Y cellsSemantic proximity Read ↗

Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPsSemantic proximity Read ↗

mRNA in cancer immunotherapy: beyond a source of antigenSemantic proximity Read ↗

Systemic trafficking of mRNA lipid nanoparticle vaccine following intramuscular injection generates potent tissue-specific T cell responseSemantic proximity Read ↗

The Emerging Role of In Vitro-Transcribed mRNA in Adoptive T Cell ImmunotherapySemantic proximity Read ↗

2-arm-PEG-oligocations transiently shield the liver sinusoids to mitigate off-target hepatic expression of mRNA lipid nanoparticlesSemantic proximity Read ↗

DNA-Directed Assembly of Multivalent Lipid Nanoparticles for Targeted T Cell Gene DeliverySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.