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The Emerging Role of In Vitro-Transcribed mRNA in Adoptive T Cell Immunotherapy

1 Feb 2019

Abstract excerpt

Adoptive T cell therapy is a form of cellular therapy that utilizes human immune cells, often empowered by the expression of recombinant proteins, to attack selected targets present on tumor or infected cells. T cell-based immunotherapy has been progressing over the past several decades, and reached a milestone with the recent US Food and Drug Administration (FDA) approval of chimeric antigen receptor T cell...

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PMID: 30819612
DOI: 10.1016/j.ymthe.2019.01.018

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