DDR1 and MT1-MMP Expression Levels Are Determinant for Triggering BIK-Mediated Apoptosis by 3D Type I Collagen Matrix in Invasive Basal-Like Breast Carcinoma Cells

Abstract excerpt

Type I collagen is the major adhesive component in breast interstitial stroma which represent the first stromal barrier against tumor invasion. We have previously shown that type I collagen activates DDR1 which plays a key role in cell growth suppression and BIK-induced apoptosis in non-invasive luminal-like breast carcinoma cells. We have also shown that MT1-MMP is able to rescue these cells and protect them...

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