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Article

Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis

17 May 2019

Abstract excerpt

The surface protein haemagglutinin (HA) of influenza A viruses (IAV) needs to be cleaved by a host protease to become functional. Here, we investigated if IAV of the H10 subtype also requires TMPRSS2 for replication and pathogenesis in mice. We first showed in cell culture that TMPRSS2 is able to cleave H10-HA. When Tmprss2−/− deficient mice were infected with a re-assorted virus H10-HA, they did not lose body...

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PMID: 31099738
DOI: 10.1099/jgv.0.001274

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