Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influenza type A virus escape mutants emerge in vivo in the presence of antibodies to the ectodomain of matrix protein 2.

Journal of virology - 1 Jun 2005

Zharikova Darya, Mozdzanowska Krystyna, Feng Jingqi, Zhang Manxin, Gerhard Walter

Abstract excerpt

The ectodomain of matrix protein 2 (M2e) of human influenza type A virus strains has remained remarkably conserved since 1918. Because M2e-specific immunity has been shown to decrease morbidity and mortality associated with influenza virus infection in several animal models and because natural infection and current vaccines do not appear to induce a good M2e-specific antibody (Ab) response, M2e has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Antibodies, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Viral

Share to Influenza A virus

Share to Influenza, Human

Share to Influenza Vaccines

Share to Mice, SCID

Share to Viral Matrix Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 15890902
DOI: 10.1128/JVI.79.11.6644-6654.2005
PMCID: PMC1112148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influenza type A virus escape mutants emerge in vivo in the presence of antibodies to the ectodomain of matrix protein 2.PMID 15890902Read ↗

In Vivo Therapy with M2e-Specific IgG Selects for an Influenza A Virus Mutant with Delayed Matrix Protein 2 Expression.Semantic proximity Read ↗

Non-neutralizing antibodies to influenza A matrix-protein-2-ectodomain are broadly effective therapeutics and resistant to viral escape mutations.Semantic proximity Read ↗

Structure of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus in Complex with a Protective Monoclonal AntibodySemantic proximity Read ↗

Matrix Protein 2 Vaccination and Protection against Influenza Viruses, Including Subtype H5N1Semantic proximity Read ↗

A Low-Dose Triple Antibody Cocktail Against the Ectodomain of the Matrix Protein 2 of Influenza A Is A Universally Effective and Viral Escape Mutant Resistant Therapeutic AgentSemantic proximity Read ↗

Monoclonal antibody recognizing SLLTEVET epitope of M2 protein potently inhibited the replication of influenza A viruses in MDCK cells.Semantic proximity Read ↗

Vaccination with M2e-based multiple antigenic peptides: characterization of the B cell response and protection efficacy in inbred and outbred mice.Semantic proximity Read ↗

Conserved epitopes of influenza A virus inducing protective immunity and their prospects for universal vaccine developmentSemantic proximity Read ↗

Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A virusesSemantic proximity Read ↗

Cross-Protective Efficacy of Influenza Virus M2e Containing Virus-Like Particles Is Superior to Hemagglutinin Vaccines and Variable Depending on the Genetic Backgrounds of MiceSemantic proximity Read ↗

VLPs Containing Stalk Domain and Ectodomain of Matrix Protein 2 of Influenza Induce Protection in MiceSemantic proximity Read ↗

M2e-Based Influenza Vaccines with Nucleoprotein: A ReviewSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.