Article
Pharmacogenetic randomized trial for cocaine abuse: disulfiram and dopamine β-hydroxylase.
Biological psychiatry - 1 Feb 2013
Kosten Thomas R, Wu Guiying, Huang Wen, Harding Mark J, Hamon Sara C, Lappalainen Jaakko, Nielsen David A
Abstract excerpt
BACKGROUND: Disulfiram has been an effective cocaine addiction pharmacotherapy, and one of its possible mechanisms of efficacy is through copper chelation and inhibition of an enzyme involved in catecholamine metabolism, dopamine β-hydroxylase (DβH), which converts dopamine to norepinephrine. A variant in the gene encoding DβH leads to reduced DβH activity, and as such, disulfiram might not be an effective...
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