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HNF4α pathway mapping identifies wild-type IDH1 as a targetable metabolic node in gastric cancer

8 May 2019

Abstract excerpt

Objective Gastric cancer (GC) is a leading cause of cancer mortality. Previous studies have shown that hepatocyte nuclear factor-4α (HNF4α) is specifically overexpressed in GC and functionally required for GC development. In this study, we investigated, on a genome-wide scale, target genes of HNF4α and oncogenic pathways driven by HNF4α and HNF4α target genes. Design We performed HNF4α chromatin...

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PMID: 31068366
DOI: 10.1136/gutjnl-2018-318025

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