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Article

Does HLA-dependent chimerism underlie the pathogenesis of juvenile dermatomyositis?

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2004

Reed Ann M, McNallan Kelly, Wettstein Peter, Vehe Richard, Ober Carole

Abstract excerpt

Juvenile dermatomyositis (JDM) is a multisystem autoimmune disease that at times resembles chronic graft-vs-host disease. This led us to suggest that nonself cells may play a role in the disease process. In this study we examined the relationship between HLA genotype and the presence of maternally derived chimeric cells in JDM patients and healthy controls, and assessed immunologic activity in the chimeric cells....

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Identifiers

PMID: 15067086
DOI: 10.4049/jimmunol.172.8.5041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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