BK Polyomavirus Activates the DNA Damage Response To Prolong S Phase

Abstract excerpt

BK polyomavirus (BKPyV) is an emerging pathogen that reactivates in immunosuppressed organ transplant patients. We wanted to understand why BKPyV-induced activation of the DNA damage response (DDR) enhances viral titers and prevents host DNA damage. Here, we show that the virus activates the DNA damage response in order to keep the infected cells in S phase to replicate the viral DNA. The source of DNA damage was...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antenna Design and Analysis
• Share to Energy Harvesting in Wireless Networks
• Share to Polyomavirus and related diseases