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Article

Viral DNA replication-dependent DNA damage response activation during BK polyomavirus infection.

Journal of virology - 1 May 2015

Verhalen Brandy, Justice Joshua L, Imperiale Michael J, Jiang Mengxi

Abstract excerpt

UNLABELLED: BK polyomavirus (BKPyV) reactivation is associated with severe human disease in kidney and bone marrow transplant patients. The interplay between viral and host factors that regulates the productive infection process remains poorly understood. We have previously reported that the cellular DNA damage response (DDR) is activated upon lytic BKPyV infection and that its activation is required for optimal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25694603
DOI: 10.1128/JVI.03650-14
PMCID: PMC4403456

Genes

ATM
ATR

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