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Differential human antibody repertoires following Zika infection and the implications for serodiagnostics and disease outcome

26 Apr 2019

Abstract excerpt

Zika virus (ZIKV) outbreak in Americas led to extensive efforts to develop vaccines and ZIKV-specific diagnostics. In the current study, we use whole genome phage display library spanning the entire ZIKV genome (ZIKV-GFPDL) for in-depth immune profiling of IgG and IgM antibody repertoires in serum and urine longitudinal samples from individuals acutely infected with ZIKV. We observe a very diverse IgM immune...

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PMID: 31028263
DOI: 10.1038/s41467-019-09914-3

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