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Large, Stable, Contemporary Interspecies Recombination Events in Circulating Human Herpes Simplex Viruses

20 Apr 2019

Abstract excerpt

BACKGROUND: The ubiquitous human pathogens, herpes simplex virus (HSV)-1 and HSV-2, are distinct viral species that diverged approximately 6 million years ago. At least 4 small, ancient HSV-1 × HSV-2 interspecies recombination events have affected the HSV-2 genome, with recombinants and nonrecombinants at each locus circulating today. However, it is unknown whether interspecies recombination can affect other loci...

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PMID: 31016321
DOI: 10.1093/infdis/jiz199

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