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Article

Worldwide circulation of HSV-2 × HSV-1 recombinant strains.

Scientific reports - 13 Mar 2017

Koelle David M, Norberg Peter, Fitzgibbon Matthew P, Russell Ronnie M, Greninger Alex L, Huang Meei-Li, Stensland Larry, Jing Lichen, Magaret Amalia S, Diem Kurt, Selke Stacy, Xie Hong, Celum Connie, Lingappa Jairam R, Jerome Keith R, Wald Anna, Johnston Christine

Abstract excerpt

Homo sapiens harbor two distinct, medically significant species of simplexviruses, herpes simplex virus (HSV)-1 and HSV-2, with estimated divergence 6-8 million years ago (MYA). Unexpectedly, we found that circulating HSV-2 strains can contain HSV-1 DNA segments in three distinct genes. Using over 150 genital swabs from North and South America and Africa, we detected recombinants worldwide. Common, widely...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28287142
DOI: 10.1038/srep44084
PMCID: PMC5347006

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