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Article

Epigenetic control of Foxp3 in intratumoral T-cells regulates growth of hepatocellular carcinoma

21 Apr 2019

Abstract excerpt

Capability of tumor cells to impede immune response are largely associated with their interaction and regulation of CD4+CD25+ forkhead box transcription factor (Foxp)3+ regulatory T (Treg) cells, which suppress cytotoxic T cell-mediated immunity in the tumor microenvironment. Foxp3 level is critical for development and phenotypic maintenance of Treg, and is regulated by transcriptional control and epigenetic...

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PMID: 31006654
DOI: 10.18632/aging.101918

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