Article
Neutrophil-delivered myeloperoxidase dampens the hydrogen peroxide burst after tissue wounding in zebrafish.
Current biology : CB - 9 Oct 2012
Pase Luke, Layton Judith E, Wittmann Christine, Ellett Felix, Nowell Cameron J, Reyes-Aldasoro Constantino Carlos, Varma Sony, Rogers Kelly L, Hall Chris J, Keightley M Cristina, Crosier Philip S, Grabher Clemens, Heath Joan K, Renshaw Stephen A, Lieschke Graham J
Abstract excerpt
Prompt neutrophil arrival is critical for host defense immediately after injury [1-3]. Following wounding, a hydrogen peroxide (H(2)O(2)) burst generated in injured tissues is the earliest known leukocyte chemoattractant [4]. Generating this tissue-scale H(2)O(2) gradient uses dual oxidase [4] and neutrophils sense H(2)O(2) by a mechanism involving the LYN Src-family kinase [5], but the molecular mechanisms...
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