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Article

Prohibitin promotes dedifferentiation and is a potential therapeutic target in neuroblastoma

22 Apr 2019

Abstract excerpt

Gain of the long arm of chromosome 17 (17q) is a cytogenetic hallmark of high-risk neuroblastoma, yet its contribution to neuroblastoma pathogenesis remains incompletely understood. Combining whole-genome and RNA sequencing of neuroblastomas, we identified the prohibitin (PHB) gene as highly expressed in tumors with 17q gain. High PHB expression correlated with poor prognosis and was associated with loss of gene...

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PMID: 30998507
DOI: 10.1172/jci.insight.127130

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