Identification of FAM53C as a cytosolic-anchoring inhibitory binding protein of the kinase DYRK1A

Abstract excerpt

The protein kinase DYRK1A encoded in human chromosome 21 is the major contributor to the multiple symptoms observed in Down syndrome patients. In addition, DYRK1A malfunction is associated with various other neurodevelopmental disorders such as autism spectrum disorder. Here we identified FAM53C with no hitherto known biological function as a novel suppressive binding partner of DYRK1A. FAM53C bound to the catalyt...

Topics

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• Alzheimer's disease research and treatments
• Down syndrome and intellectual disability research
• Galectins and Cancer Biology
• Neuroblastoma Research and Treatments
• Peptidase Inhibition and Analysis
• Signaling Pathways in Disease
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

429d00d2-c7fd-5a41-a205-35cdb5eb23b0

DOI

10.1101/2023.04.21.537794