Article
Phenotype and function of IL-10-producing NK cells in individuals with malaria experience.
JCI insight - 8 May 2025
McNitt Sarah A, Dick Jenna K, Hernandez-Castaneda Maria Andrea, Sangala Jules, Pierson Mark, Macchietto Marissa, Burrack Kristina S, Crompton Peter D, Seydel Karl, Hamilton Sara E, Hart Geoffrey T
Abstract excerpt
P.falciparum infection can trigger high levels of inflammation that lead to fever and sometimes severe disease. People living in malaria-endemic areas gradually develop resistance to symptomatic malaria and control both parasite numbers and the inflammatory response. We previously found that adaptive NK cells correlated with reduced parasite load and protection from symptoms. We also found that murine NK cell...
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