Characterization of an isogenic bimA mutant in the ATS2021 strain of Burkholderia pseudomallei.

doi:10.1128/iai.00727-25

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Characterization of an isogenic bimA mutant in the ATS2021 strain of Burkholderia pseudomallei.

Infection and immunity - 14 Jul 2026

Cote Christopher K, Mou Sherry, Davies Michael L, Mlynek Kevin D, Klimko Christopher P, Biryukov Sergei S, Rill Nathaniel O, Dankmeyer Jennifer L, Wheeler Taloria K, Rodriguez Carlos I, Smith Brian A, Hunter Melissa, Martinez Elsie I, Douglas Christina E, Taylor-Howell Cheryl, Hoj Taalin S, Stefan Christopher P, Qiu Ju, Zeng Xiankun, Bozue Joel A, Twenhafel Nancy A, Shoemaker Charles J, DeShazer David

Abstract excerpt

Encephalomyelitis is uncommon but is associated with Burkholderia pseudomallei strains whose bimA gene, encoding an actin-based motility protein, resembles bimA from Burkholderia mallei (designated bimABm). We previously characterized the virulence of B. pseudomallei wild-type ATS2021 (bimABm). In a mouse model of ATS2021 aerosol exposure, lesions and inflammatory cytokines in the brain were seen early...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain

Share to Burkholderia pseudomallei

Share to Disease Models, Animal

Source

Open in PubMed Open full text

Identifiers

PMID: 42312865
DOI: 10.1128/iai.00727-25
PMCID: PMC13367048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of an isogenic bimA mutant in the ATS2021 strain of Burkholderia pseudomallei.PMID 42312865Read ↗

Increased Neurotropic Threat from Burkholderia pseudomallei Strains with a B. mallei-like Variation in the bimA Motility Gene, Australia.Semantic proximity Read ↗

Melioidosis of the Central Nervous System: Impact of the bimA Bm Allele on Patient Presentation and OutcomeSemantic proximity Read ↗

Burkholderia pseudomallei BimC Is Required for Actin-Based Motility, Intracellular Survival, and VirulenceSemantic proximity Read ↗

Genetic variation, structural analysis, and virulence implications of BimA and BimC in clinical isolates of Burkholderia pseudomallei in Thailand.Semantic proximity Read ↗

Burkholderia pseudomallei BicA protein promotes pathogenicity in macrophages by regulating Invasion, Intracellular Survival, and VirulenceSemantic proximity Read ↗

Characterization of the murine macrophage response to infection with virulent and avirulent Burkholderia speciesSemantic proximity Read ↗

Functional Characterization of Burkholderia pseudomallei Trimeric AutotransportersSemantic proximity Read ↗

Autotransporters and Their Role in the Virulence of Burkholderia pseudomallei and Burkholderia malleiSemantic proximity Read ↗

Burkholderia pseudomallei Capsule Exacerbates Respiratory Melioidosis but Does Not Afford Protection against Antimicrobial Signaling or Bacterial Killing in Human Olfactory Ensheathing Cells.Semantic proximity Read ↗

Comparing in vitro and in vivo virulence phenotypes of Burkholderia pseudomallei type G strains.Semantic proximity Read ↗

Variable Virulence Factors in Burkholderia pseudomallei (Melioidosis) Associated with Human DiseaseSemantic proximity Read ↗

Clinical Burkholderia pseudomallei isolates from Queensland carry diverse bimABm genes that are associated with central nervous system disease and are phylogenomically distinct from other Australian strainsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.