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Intra-patient viral evolution in polyomavirus-related diseases

8 Apr 2019

Abstract excerpt

Human polyomaviruses show relatively little genetic polymorphism between isolates, indicating that these viruses are genetically stable between hosts. However, it has become increasingly clear that intra-host molecular evolution is a feature of some polyomavirus (PyV) infections in humans. Mutations inducing premature stop codons in the early region of the integrated Merkel cell PyV genome lead to the expression...

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PMID: 30955497
DOI: 10.1098/rstb.2018.0301

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