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The two‐faced nature of BK polyomavirus: lytic infection or non‐lytic large‐T‐positive carcinoma

22 Jun 2018

Abstract excerpt

In immunocompromised patients, reactivation of latent BK polyomavirus (BKPyV) can cause disease with lytic infections of the kidneys and the lower urinary tract. Emerging evidence also links BKPyV to oncogenesis and high-grade intrarenal and transitional cell carcinomas. These neoplasms strongly express polyomavirus large-T antigen as a defining feature; that is, they are 'large-T-positive carcinomas'. Such...

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PMID: 29931826
DOI: 10.1002/path.5127

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