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Article

Intra-host genomic diversity and integration landscape of human tissue-resident DNA virome.

Nucleic acids research - 27 Nov 2024

Pyöriä Lari, Pratas Diogo, Toppinen Mari, Simmonds Peter, Hedman Klaus, Sajantila Antti, Perdomo Maria F

Abstract excerpt

The viral intra-host genetic diversities and interactions with the human genome during decades of persistence remain poorly characterized. In this study, we analyzed the variability and integration sites of persisting viruses in nine organs from thirteen individuals who died suddenly from non-viral causes. The viruses studied included parvovirus B19, six herpesviruses, Merkel cell (MCPyV) and JC polyomaviruses,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39436041
DOI: 10.1093/nar/gkae871
PMCID: PMC11602146

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