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Article

SIRT5 downregulation is associated with poor prognosis in glioblastoma

19 Mar 2019

Abstract excerpt

OBJECTIVE: Sirtuins (SIRT) are NAD+-dependent protein deacetylases that are involved in the regulation of cancer-associated pathways. However, the biological role of these deacetylases remains elusive in glioblastoma (GBM). Here, we evaluated the effects of 7 sirtuins regarding their occurrence and prognostic value for GBM. METHODS: In this research, the effects of SIRT5 on the occurrence and prognosis of GBM...

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PMID: 30909186
DOI: 10.3233/cbm-182197

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